Chief Medical & Clinical Affairs Officer, Neurovascular Devices – Boston, MA

Role Overview for Chief Medical & Clinical Affairs Officer, Neurovascular Devices – Boston, MA

JRG Partners is proud to lead the exclusive search for a Chief Medical & Clinical Affairs Officer on behalf of our client, a pioneering, venture-backed neurovascular device company based in the vibrant life sciences hub of Boston, MA. This organization is at the forefront of developing next-generation technologies designed to revolutionize the treatment of complex neurovascular conditions, including ischemic and hemorrhagic strokes, cerebral aneurysms, and arteriovenous malformations (AVMs). Their mission is to dramatically improve patient outcomes and set new standards of care through relentless innovation and scientific rigor.

This is a career-defining opportunity for a visionary and experienced physician executive to join a dynamic and fast-paced leadership team. The Chief Medical & Clinical Affairs Officer (CMO) will serve as the cornerstone of the company’s clinical and medical strategy, providing the enterprise-wide vision, leadership, and execution necessary to bring groundbreaking products through the clinical development lifecycle to global commercialization. As the senior-most medical authority in the company, the CMO will be responsible for the scientific integrity and clinical success of the entire product portfolio. This executive will be instrumental in shaping the company’s future, influencing R&D, guiding regulatory strategy, and building a world-class Medical and Clinical Affairs organization. The ideal candidate is a strategic thinker, an inspirational leader, and a subject matter expert in the neurovascular field, passionate about translating innovative science into life-saving medical solutions for patients worldwide.

Key Responsibilities of Chief Medical & Clinical Affairs Officer, Neurovascular Devices – Boston, MA

The Chief Medical & Clinical Affairs Officer will have a broad and impactful remit, overseeing all aspects of the company’s medical and clinical functions. Key responsibilities include:

Strategic Clinical & Medical Leadership

• Develop, articulate, and execute the long-term global clinical development strategy for the company’s entire neurovascular device portfolio, ensuring alignment with overall corporate objectives.
• Serve as the primary medical and clinical expert for the company, providing authoritative guidance to the Board of Directors, executive team, investors, and internal departments.
• Provide critical medical and scientific input into the product pipeline, from early-stage research and ideation through product development, lifecycle management, and next-generation enhancements.
• Establish and chair the company’s Clinical Advisory Board and Scientific Advisory Boards, fostering collaborative relationships with global thought leaders to inform clinical and product strategy.
• Continuously monitor and analyze the competitive landscape, emerging scientific data, and evolving clinical practices to ensure the company remains at the cutting edge of neurovascular medicine.

Clinical Trial Design & Execution

• Provide ultimate oversight for the design, planning, and execution of all clinical trials, including early feasibility, pivotal pre-market studies, and post-market registries and surveillance studies.
• Ensure all clinical trials are conducted on time, within budget, and in strict compliance with Good Clinical Practice (GCP), ISO 14155, and all applicable global regulatory requirements.
• Lead the strategic selection and management of world-class Clinical Research Organizations (CROs), academic research partners, and clinical trial sites.
• Direct the biostatistics and data management functions to ensure robust data collection, rigorous analysis, and accurate interpretation and reporting of clinical trial results.

Regulatory Affairs & Device Safety

• Serve as the senior medical leader in all interactions with global regulatory authorities, including the FDA, Notified Bodies, and other international agencies.
• Lead the development and authoring of the clinical sections of all regulatory submissions, including Investigational Device Exemptions (IDEs), Premarket Approvals (PMAs), 510(k)s, and CE Mark technical files.
• Establish and oversee robust, compliant, and efficient post-market surveillance and medical safety/vigilance programs to monitor the real-world performance and safety of commercialized products.
• Provide medical review and final sign-off for all adverse event reporting and risk management activities, ensuring patient safety is the highest priority.

Medical Affairs & Scientific Communications

• Develop and maintain strong, collaborative relationships with global Key Opinion Leaders (KOLs), principal investigators, and leading scientific societies in the neurovascular community.
• Define and execute a comprehensive scientific communications and publication strategy to effectively disseminate clinical trial data and support the value proposition of the company’s technologies in peer-reviewed journals and at major medical congresses.
• Oversee the Medical Science Liaison (MSL) team and medical information functions to provide accurate and balanced scientific exchange with healthcare professionals.
• Ensure the medical and scientific accuracy and integrity of all external-facing materials, including marketing collateral, training documents, and educational programs.

Executive & Team Leadership

• Serve as a proactive and influential member of the executive leadership team, contributing to overall corporate strategy, fundraising activities, and business development initiatives.
• Build, mentor, and lead a high-performing, agile, and scientifically-driven Medical and Clinical Affairs organization.
• Develop and manage departmental budgets, resource allocation, and long-range operational plans to support corporate goals.
• Champion a corporate culture of scientific rigor, ethical conduct, collaboration, and an unwavering focus on the needs of patients.

Requirements for the Chief Medical & Clinical Affairs Officer, Neurovascular Devices – Boston, MA

Educational & Professional Qualifications

• An M.D. (Medical Doctor) or equivalent degree is required.
• Specialization and training in a relevant clinical field such as Neurology, Neurosurgery, or Interventional Neuroradiology is strongly preferred.
• An advanced degree (e.g., PhD in a related science, MBA) is considered a significant plus.
• Board certification in a relevant medical specialty is highly desirable.

Experience

• A minimum of 15 years of progressive experience within the medical device, biopharmaceutical, or life sciences industry, with a substantial portion of that time focused on clinical development and medical affairs.
• At least 7-10 years of experience in a senior leadership role (e.g., Vice President, Senior Director, CMO) with direct management of Clinical and/or Medical Affairs functions and teams.
• Essential, in-depth, and hands-on experience in the neurovascular therapeutic area (e.g., devices for ischemic stroke, hemorrhagic stroke, cerebral aneurysms, AVMs) is a mandatory requirement for this position.
• A demonstrated track record of successfully leading complex clinical programs from early development through to regulatory approval and commercial launch in the US and Europe.
• Proven, first-hand experience interacting directly with the FDA (CDRH) and other global regulatory bodies, and a history of successful regulatory submissions.
• Experience working in both large, established companies and small, fast-paced startup environments is highly advantageous.

Skills & Competencies

• A visionary leader with exceptional strategic thinking, analytical, and problem-solving skills, capable of navigating ambiguity and making sound decisions.
• Deep and current knowledge of clinical trial methodologies, biostatistics, epidemiology, and the interpretation of complex clinical data.
• Comprehensive understanding of the global regulatory landscape for medical devices, including a deep familiarity with FDA and EMA guidelines and regulations.
• Exceptional communication, presentation, and interpersonal skills, with the ability to influence and build consensus with diverse audiences, from neurosurgeons to investors.
• An established and credible network of contacts and Key Opinion Leaders within the international neurovascular community.
• Strong business acumen with the ability to align clinical strategy with commercial goals and financial realities.

Benefits & Perks Offered

Our client offers a highly competitive and comprehensive compensation package designed to attract and retain a top-tier executive leader. This includes:

• Competitive executive base salary and an attractive annual performance-based bonus.
• A significant equity/stock option grant, providing a meaningful opportunity for wealth creation.
• A comprehensive benefits package, including premium medical, dental, vision, and life insurance.
• A 401(k) retirement savings plan with a generous company match.
• Flexible Paid Time Off (PTO) policy and paid company holidays.
• A full relocation package for the successful candidate and their family, if required.
• A generous budget for professional development, attendance at major medical conferences, and continued medical education.
• The invaluable opportunity to work in a dynamic, mission-driven environment where your contributions will directly impact patient lives and shape the future of neurovascular care.

How to Apply

JRG Partners is the exclusive search firm retained for this critical Chief Medical & Clinical Affairs Officer recruitment. We invite qualified and interested candidates to apply for this unique opportunity to make a lasting impact. To be considered for this pivotal leadership role, please submit your CV and a detailed cover letter outlining your relevant experience and interest in the position. JRG Partners specializes in connecting top-tier talent with transformative companies in the healthcare sector. Learn more about our expertise by visiting our Orthopedic Devices Executive Search Firm practice.