Role Overview for Head of Gene Therapy R&D
JRG Partners, a premier executive search firm specializing in life sciences, is thrilled to partner with an innovative, rapidly growing biotechnology company at the forefront of gene therapy. We are seeking a visionary and highly accomplished Head of Gene Therapy R&D to lead the scientific strategy and execution of our client’s groundbreaking gene therapy pipeline. This is an unparalleled opportunity to shape the future of medicine, bringing curative treatments to patients suffering from severe genetic diseases.
Our client is a dynamic and well-funded organization with a robust portfolio of preclinical and clinical-stage programs. They are committed to pushing the boundaries of scientific innovation, leveraging cutting-edge technologies in viral vector design, gene editing, and delivery systems.
As the Head of Gene Therapy R&D, you will be a pivotal member of the senior leadership team, responsible for driving the overall R&D strategy, overseeing all aspects from target identification through preclinical development and IND-enabling studies, and guiding programs into clinical trials. You will build, mentor, and inspire a world-class team of scientists and researchers, fostering a culture of scientific rigor, collaboration, and urgent patient focus.
This role demands a leader with deep scientific expertise in gene therapy, a proven track record of successful drug development, and exceptional strategic acumen. You will be instrumental in translating novel scientific discoveries into therapeutic candidates, navigating complex scientific challenges, and contributing significantly to the company’s long-term growth and success. If you are passionate about making a profound impact on human health and thrive in a fast-paced, entrepreneurial environment, we invite you to explore this transformative opportunity.
Key Responsibilities of Head of Gene Therapy R&D
Strategic Leadership & Vision
Define and execute the overall R&D strategy for the gene therapy portfolio, ensuring alignment with corporate objectives and long-term vision. Identify and evaluate new therapeutic targets, platforms, and technologies to expand the pipeline.
Scientific & Technical Oversight
Provide expert scientific and technical leadership across all stages of gene therapy R&D, from discovery to preclinical development, IND-enabling studies, and early clinical translation. Oversee experimental design, data interpretation, and decision-making for all research programs.
Pipeline Management
Drive the progression of gene therapy candidates through the discovery and preclinical development phases. Ensure timely execution of key milestones, manage resources effectively, and mitigate scientific and operational risks.
Team Building & Mentorship
Recruit, develop, and retain a high-performing team of scientists and research associates. Foster a collaborative, innovative, and results-oriented scientific culture, promoting professional growth and scientific excellence.
Cross-functional Collaboration
Work closely with Clinical Development, Regulatory Affairs, Manufacturing (CMC), Business Development, and other internal stakeholders to ensure seamless program advancement. Represent R&D in internal strategic discussions and executive leadership meetings.
External Engagement & Partnerships
Establish and maintain strong relationships with key opinion leaders (KOLs), academic collaborators, and industry partners. Evaluate potential in-licensing opportunities, collaborations, and strategic alliances to augment the R&D pipeline. Present research findings at scientific conferences and publish in peer-reviewed journals.
Regulatory Strategy
Contribute to the development of regulatory strategies for gene therapy programs, including IND submissions, and interact with regulatory agencies as required. Ensure all R&D activities adhere to GxP guidelines and relevant regulatory requirements.
Budget & Resource Management
Manage the R&D budget, allocate resources efficiently, and ensure judicious use of financial and personnel resources to achieve scientific and corporate goals.
Intellectual Property
Work with legal counsel to identify, protect, and expand the company’s intellectual property portfolio related to gene therapy technologies and product candidates.
Requirements for the Head of Gene Therapy R&D
Education
Ph.D. in Molecular Biology, Genetics, Virology, Immunology, Biochemistry, or a closely related scientific discipline is required.
Experience
- Minimum of 15+ years of progressive experience in biotechnology or pharmaceutical R&D, with at least 8-10 years specifically focused on gene therapy development.
- Significant leadership experience (8+ years) managing and mentoring scientific teams in a fast-paced industry setting, preferably at a Director, Senior Director, or VP level.
- Demonstrated track record of successfully advancing gene therapy programs from discovery through preclinical development to IND submission and early clinical stages.
- Proven experience in strategic planning, budget management, and resource allocation for R&D initiatives.
Technical Expertise
- Deep scientific understanding and hands-on experience with various gene therapy modalities, including AAV, lentiviral vectors, non-viral delivery systems, and gene editing technologies (e.g., CRISPR/Cas9).
- Strong knowledge of molecular biology, cell biology, virology, immunology, and genetics relevant to gene therapy.
- Experience with preclinical models of human disease, biomarker discovery, and translational research.
- Familiarity with CMC considerations for gene therapy products, including vector manufacturing, analytics, and quality control.
- Understanding of the regulatory landscape for gene therapies and experience interacting with regulatory authorities (e.g., FDA, EMA).
Leadership & Soft Skills
- Exceptional leadership abilities with a proven capacity to inspire, motivate, and develop scientific talent.
- Outstanding strategic thinking, problem-solving, and decision-making skills.
- Excellent written and verbal communication skills, with the ability to effectively articulate complex scientific concepts to diverse audiences, including executive leadership, scientific teams, and external partners.
- Strong interpersonal skills and a demonstrated ability to build effective relationships and foster collaboration across functions and externally.
- Ability to thrive in a dynamic, high-growth environment, managing multiple priorities and adapting to evolving scientific and business needs.
Benefits & Perks Offered
Our client offers a highly competitive compensation package designed to attract and retain top-tier talent in the gene therapy space. This includes a robust base salary, significant equity participation, and a performance-based bonus structure that rewards innovation and achievement. Beyond financial incentives, the company is committed to fostering a supportive and enriching work environment.
Comprehensive Health & Wellness
Premium medical, dental, and vision insurance plans for employees and their families, with low out-of-pocket costs. Access to wellness programs, mental health support, and employee assistance programs.
Financial Security
Generous 401(k) retirement plan with company matching contributions, immediate vesting, and financial planning resources. Life insurance, short-term, and long-term disability coverage.
Work-Life Balance
Flexible paid time off (PTO) policy, including vacation, sick leave, and company holidays. Potential for flexible work arrangements where applicable.
Professional Development
Opportunities for continuous learning and career advancement through internal training programs, external conferences, workshops, and tuition reimbursement for relevant certifications or advanced degrees.
Innovative Environment
Work in state-of-the-art research facilities equipped with cutting-edge technologies. Engage with leading scientists and contribute to a culture of scientific excellence and groundbreaking discovery.
Impactful Work
Be part of a mission-driven company dedicated to developing life-changing therapies for patients with unmet medical needs. Witness the direct impact of your contributions on human health.
Collaborative Culture
Join a diverse and inclusive team that values collaboration, open communication, and mutual respect. Regular team-building events, social gatherings, and a vibrant company culture.
Relocation Assistance
For exceptional candidates relocating to the Boston area, comprehensive relocation support may be provided.
How to Apply
If you are a highly motivated and experienced scientific leader ready to take on a pivotal role in shaping the future of gene therapy, we encourage you to apply. This is a unique opportunity to join a rapidly advancing company with a significant impact on patient lives.
Please submit your resume and a cover letter detailing your relevant experience and why you are an ideal candidate for this Head of Gene Therapy R&D position through the JRG Partners application portal. For more information about JRG Partners and our expertise in executive search for the life sciences industry, please visit our Life Sciences Executive Search practice area page.
JRG Partners is an equal opportunity employer and values diversity. All employment decisions are based on qualifications, merit, and business need. We encourage applications from all qualified individuals regardless of race, color, religion, sex, national origin, disability, protected veteran status, or any other legally protected status.
