Role Overview for EVP, Global Drug Discovery with a Biopharma Start-up – Cambridge, MA
JRG Partners is proud to represent a well-funded, innovative biopharmaceutical start-up poised to redefine the treatment landscape for complex diseases. Located in the heart of the global biotech hub in Cambridge, MA, our client is seeking a visionary and transformative Executive Vice President (EVP) of Global Drug Discovery.
This is a paramount leadership position, reporting directly to the Chief Executive Officer, and serving as a critical member of the executive leadership team. The successful candidate will be the architect and driver of the company’s entire discovery engine, responsible for building and leading a world-class research organization. You will set the strategic direction for all discovery efforts, from novel target identification and validation through to the delivery of high-quality, IND-ready drug candidates.
This role offers a unique opportunity to shape the scientific foundation of a burgeoning company, cultivate a culture of relentless innovation, and ultimately deliver life-changing therapies to patients in need. You will have the autonomy, resources, and executive support to build a discovery portfolio that is both scientifically rigorous and strategically aligned with the company’s long-term vision. This executive will be instrumental in translating groundbreaking science into a robust pipeline of first-in-class or best-in-class therapeutics.
Key Responsibilities of EVP, Global Drug Discovery with a Biopharma Start-up – Cambridge, MA
The EVP, Global Drug Discovery will have broad accountability for the company’s research pipeline and scientific strategy. This includes, but is not limited to, the following responsibilities:
Strategic Leadership & Vision
Develop, articulate, and execute a comprehensive global drug discovery strategy that aligns with the company’s corporate goals and long-term vision. Identify and champion new therapeutic areas, cutting-edge technologies, and novel biological targets to ensure a sustainable and competitive pipeline.
Pipeline Delivery & Execution
Provide scientific and operational oversight for all discovery programs. Lead the entire discovery process, including target identification, validation, assay development, high-throughput screening, medicinal chemistry, DMPK, pharmacology, and toxicology, ensuring the timely delivery of high-quality development candidates.
Team Leadership & Development
Recruit, lead, mentor, and develop a high-performing, multi-disciplinary team of scientists. Foster a dynamic, collaborative, and scientifically rigorous culture that encourages innovation, risk-taking, and a sense of urgency. Champion professional development and create growth opportunities for team members.
Scientific Innovation
Stay at the forefront of scientific and technological advancements in drug discovery. Champion and implement novel platforms, methodologies (such as AI/ML, CRISPR, proteomics), and approaches to enhance the efficiency and success rate of the discovery engine.
Cross-Functional Collaboration
Serve as a key partner to other executive leaders, including the heads of Clinical Development, Regulatory Affairs, and Business Development. Ensure seamless transitions of programs from discovery to development and provide scientific expertise to support corporate strategy and external partnerships.
Resource Management
Develop and manage the drug discovery budget, ensuring optimal allocation of resources, personnel, and capital to priority programs. Oversee external research collaborations, including CROs and academic partners, to augment internal capabilities.
External Engagement & Communication
Represent the company’s scientific platform and discovery portfolio to the Board of Directors, investors, scientific advisors, and potential partners. Build a strong external network and present the company’s research at major scientific conferences. Ensure the company’s scientific achievements are communicated effectively through high-impact publications.
Regulatory Strategy
Collaborate closely with the regulatory team to build robust data packages and successfully navigate the complex journey from discovery to IND filing, ensuring all preclinical activities meet global regulatory standards.
Requirements for the EVP, Global Drug Discovery with a Biopharma Start-up – Cambridge, MA
We are seeking a seasoned and accomplished scientific leader with a proven track record of success in building and leading drug discovery organizations.
Educational Background
An M.D., Ph.D., or M.D./Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Chemistry) is required.
Executive Experience
A minimum of 15-20 years of progressive experience in the biopharmaceutical industry, with at least 10 years in a senior leadership role overseeing multi-disciplinary drug discovery teams and functions. Experience in a fast-paced, start-up or biotech environment is highly preferred.
Proven Track Record of Success
Demonstrated success in leading drug discovery programs from initial concept through to IND submission and into early clinical development. A strong portfolio of successful programs and a solid publication/patent record are essential.
Deep Scientific Expertise
Broad and deep expertise across multiple therapeutic modalities (e.g., small molecules, biologics, cell/gene therapies) and therapeutic areas (e.g., oncology, immunology, neurology, rare diseases).
Exceptional Leadership Skills
A strategic thinker with the ability to inspire and motivate teams. Proven ability to recruit and retain top-tier scientific talent. A collaborative leader who can effectively influence and work across a matrixed organization.
Strong Business Acumen
A sophisticated understanding of the entire drug development lifecycle, including clinical, regulatory, and commercial considerations. Experience in evaluating external assets and contributing to due diligence for business development activities is a plus.
Outstanding Communication Skills
The ability to clearly and compellingly communicate complex scientific concepts to a wide range of audiences, from internal scientific teams to external stakeholders, including investors and partners.
Benefits & Perks Offered
Our client is committed to attracting and retaining top talent by offering a highly competitive and comprehensive compensation and benefits package. As a key member of the executive team, you can expect:
Competitive Base Salary
An attractive base salary commensurate with executive-level experience and market standards.
Significant Equity Stake
A substantial equity package (stock options) providing a meaningful opportunity for ownership and financial reward tied to the company’s success.
Performance-Based Bonus
A generous annual bonus plan based on the achievement of individual and corporate milestones.
Comprehensive Health Coverage
Premium medical, dental, and vision insurance plans for you and your eligible dependents.
Retirement Savings
A 401(k) plan with a generous company match to help you plan for your future.
Generous Paid Time Off
A flexible and generous vacation, sick leave, and holiday policy to support a healthy work-life balance.
Professional Development
A dedicated budget for attending conferences, workshops, and continuing education to foster your professional growth.
Relocation Assistance
A comprehensive relocation package is available for the right candidate.
How to Apply
This is a retained search conducted exclusively by JRG Partners. To be considered for this career-defining opportunity, please submit your resume and a cover letter detailing your qualifications and leadership philosophy. We are committed to a confidential and thorough review process. JRG Partners specializes in connecting visionary leaders with transformative companies in the life sciences sector. To learn more about our expertise and other opportunities, please visit our Life Sciences Executive Search practice area page. We look forward to hearing from you.
