Role Overview for Chief Medical Officer, Biotech – San Diego, CA
JRG Partners has been exclusively retained to identify a visionary and experienced Chief Medical Officer (CMO) for our client, a pioneering, clinical-stage biotechnology company based in the vibrant life sciences hub of San Diego, CA. This is a career-defining opportunity to join a dynamic executive team and shape the future of medicine by leading the clinical development of a novel therapeutic pipeline in oncology and rare diseases.
As the Chief Medical Officer, you will be the senior-most clinical leader in the organization, reporting directly to the Chief Executive Officer. You will hold ultimate responsibility for the overarching clinical vision, strategy, and execution of all clinical development programs. This role requires a unique blend of scientific rigor, strategic thinking, medical expertise, and inspirational leadership. You will be the company’s primary medical and scientific voice, interacting with regulatory authorities, key opinion leaders (KOLs), investors, and the Board of Directors.
The ideal candidate is a strategic, hands-on leader with a proven track record of successfully guiding novel therapies through the full lifecycle of clinical development, from first-in-human studies to regulatory approval and post-market activities. You will be instrumental in building and scaling a world-class clinical development organization, fostering a culture of innovation, collaboration, and unwavering commitment to patient safety and well-being. Your leadership will directly impact the company’s ability to deliver transformative treatments to patients with significant unmet medical needs. This position is not just a job; it is a chance to leave a lasting legacy in the biotech industry from the heart of one of its most innovative ecosystems.
Key Responsibilities of Chief Medical Officer, Biotech – San Diego, CA
The CMO will direct and oversee all aspects of the company’s clinical and medical affairs functions. Key responsibilities are comprehensive and include:
Clinical Development Strategy & Execution
Design, implement, and lead innovative, scientifically robust, and efficient clinical development plans for all pipeline assets. Oversee the entire clinical trial lifecycle, from Phase I through Phase IV, ensuring studies are conducted on time, within budget, and in full compliance with regulatory standards.
Regulatory Leadership
Serve as the primary medical liaison with global regulatory agencies. You will lead the strategy and preparation for critical regulatory interactions and submissions, including pre-IND meetings, IND applications, End-of-Phase 2 meetings, and the ultimate submission of NDAs/BLAs to the U.S. Food and Drug Administration (FDA) and other international health authorities.
Medical Affairs & Scientific Communications
Build and lead a strategic Medical Affairs function to support product commercialization. Oversee the development of publication strategies, medical information, health economics and outcomes research (HEOR), and the cultivation of strong relationships with Key Opinion Leaders (KOLs) and patient advocacy groups.
Pharmacovigilance and Patient Safety
Establish and maintain a robust pharmacovigilance and drug safety infrastructure. You will be ultimately responsible for the continuous monitoring and assessment of the benefit-risk profile of all investigational products.
Executive & Corporate Leadership
As a key member of the executive leadership team, you will contribute significantly to the overall corporate strategy, long-range planning, and business development activities. This includes participating in fundraising efforts, due diligence for potential partnerships, and representing the company’s clinical vision to investors and partners.
Team Building & Mentorship
Recruit, lead, and develop a high-performing team of professionals across Clinical Development, Clinical Operations, Medical Affairs, and Drug Safety. Foster a culture of excellence, accountability, and continuous learning.
Data Interpretation & Analysis
Provide expert medical interpretation and analysis of clinical trial data. Ensure the scientific integrity of all data generated and presented in clinical study reports, regulatory filings, and scientific publications.
Budget and Resource Management
Develop and manage the annual budget for the clinical development organization, ensuring optimal allocation of resources to achieve corporate goals and clinical milestones.
Requirements for the Chief Medical Officer, Biotech – San Diego, CA
We are seeking a highly qualified and motivated individual with a deep passion for science and patient care. The successful candidate will possess the following qualifications:
Medical Doctorate (MD)
An MD is required. A PhD, MPH, or MBA is highly desirable.
Board Certification
Board certification in a relevant medical specialty, such as Oncology, Hematology, or Internal Medicine, is strongly preferred.
Extensive Industry Experience
A minimum of 15 years of progressive experience within the biotechnology or pharmaceutical industry, with at least 5 years in a senior leadership capacity (e.g., Vice President, Senior Vice President, or CMO level).
Proven Clinical Development Expertise
A demonstrable track record of success in leading all phases of clinical development, including the design and execution of pivotal trials that have led to successful regulatory approvals.
Regulatory Acumen
Deep, hands-on experience in interacting with the FDA and other global regulatory bodies. Must have a thorough understanding of GCP, ICH guidelines, and the global regulatory landscape.
Therapeutic Area Expertise
Significant experience in oncology, immunology, or rare diseases is highly preferred.
Exceptional Leadership Skills
Proven ability to lead, influence, and motivate cross-functional teams in a fast-paced, dynamic environment. Must be an outstanding communicator with the ability to articulate complex scientific concepts to diverse audiences.
Strategic and Business Mindset
Strong business acumen with an ability to integrate clinical and scientific objectives with broader corporate strategy. Experience in a small, growing biotech environment and participation in fundraising activities is a significant plus.
Location
The candidate must be willing to be based in the San Diego, CA area, with the ability to travel as required.
Benefits & Perks Offered
Our client is committed to attracting and retaining top talent by offering a highly competitive and comprehensive compensation and benefits package. This includes:
Executive Compensation
A competitive base salary, annual performance-based bonus, and a significant equity stake (stock options) in the company.
Comprehensive Health and Wellness
Premium medical, dental, and vision insurance for you and your dependents.
Retirement Savings
A 401(k) plan with a generous company match to help you plan for your future.
Work-Life Balance
A flexible and generous paid time off (PTO) policy, including vacation, sick leave, and paid company holidays.
Relocation Support
A comprehensive relocation package is available for the successful candidate and their family.
Professional Growth
Ample opportunities for professional development, including attendance at major scientific conferences and leadership training programs.
Innovative Culture
The opportunity to work in a collaborative, science-driven, and patient-focused environment where your contributions will have a direct and meaningful impact.
How to Apply
This is a retained search being conducted by JRG Partners. If you are a visionary medical leader with the experience and passion to drive groundbreaking therapies from the clinic to patients in need, we invite you to apply. To be considered for this pivotal role, please submit your curriculum vitae and a cover letter detailing your qualifications and interest.
JRG Partners is a premier executive search firm specializing in the life sciences and healthcare sectors. We connect innovative companies with the transformative leaders who can drive their success. To learn more about our expertise and explore other opportunities, please visit the JRG Partners’ Best Biotech Recruiters practice area page. We look forward to reviewing your application.
