Role Overview for EVP, Biopharma Operations with a Biotech Firm – Cambridge, MA
JRG Partners is proud to partner with a pioneering, clinical-stage biotechnology firm at the forefront of developing transformative therapies. Located in the global life sciences hub of Cambridge, MA, our client is dedicated to addressing unmet medical needs through innovative science and a commitment to patient-centric solutions.
We are seeking a visionary and highly accomplished Executive Vice President (EVP) of Biopharma Operations to join their executive leadership team. This is a career-defining opportunity to shape the future of a dynamic organization and play a pivotal role in bringing life-changing treatments from the laboratory to patients worldwide.
The EVP of Biopharma Operations will be a strategic cornerstone of the company, providing executive leadership and oversight for all aspects of Chemistry, Manufacturing, and Controls (CMC), technical operations, supply chain management, quality assurance, and manufacturing. This individual will be responsible for building and scaling a world-class operations function capable of supporting a diverse and growing pipeline of biologic and advanced therapy products through all phases of clinical development and commercialization.
The ideal candidate is a seasoned biopharmaceutical executive with a proven track record of strategic leadership, operational excellence, and successful product lifecycle management in a fast-paced, innovative environment. You will be instrumental in developing and executing a robust operations strategy that aligns with the company’s long-term corporate objectives, ensuring product quality, regulatory compliance, and a reliable global supply chain.
Key Responsibilities of EVP, Biopharma Operations with a Biotech Firm – Cambridge, MA
Strategic Leadership & Vision
Develop and implement a comprehensive, long-range biopharma operations strategy that supports the company’s clinical development pipeline and prepares for successful commercial launches. Serve as a key member of the executive team, contributing to overall corporate strategy, goal setting, and long-term planning. Proactively identify and mitigate risks across the manufacturing and supply chain network.
CMC & Technical Operations Oversight
Provide senior leadership for all CMC activities, including process development, analytical development, formulation, and manufacturing sciences. Ensure the development of robust, scalable, and cost-effective manufacturing processes for a portfolio of complex biologics or cell/gene therapies. Oversee technology transfers to and management of Contract Development and Manufacturing Organizations (CDMOs).
Manufacturing & Supply Chain Management
Build and lead a global supply chain organization responsible for clinical and commercial supply planning, logistics, inventory management, and distribution. Establish and manage a network of external manufacturing partners (CMOs/CDMOs), ensuring they meet stringent quality, performance, and delivery standards. Develop a strategic roadmap for future internal manufacturing capabilities as the company grows.
Quality & Regulatory Compliance
Champion a culture of quality and compliance throughout the organization. Ensure all operations adhere to global regulatory standards, including strict compliance with Current Good Manufacturing Practice (cGMP) regulations. Oversee the Quality Assurance and Quality Control functions, ensuring robust systems are in place for batch release, deviation management, and supplier quality. Act as a key liaison with regulatory agencies (FDA, EMA, etc.) on all operations-related matters.
Cross-Functional Collaboration
Foster a highly collaborative environment, working closely with leaders in Research, Clinical Development, Regulatory Affairs, and Commercial teams. Ensure seamless integration of operational activities to support clinical trial execution, regulatory submissions (INDs, BLAs), and product launch readiness. Communicate complex operational updates, challenges, and strategies effectively to the executive team and Board of Directors.
Team Leadership & Development
Recruit, mentor, and develop a high-performing, multi-disciplinary operations team. Cultivate a culture of innovation, accountability, and continuous improvement. Provide strong leadership and direction, empowering team members and fostering their professional growth to build a sustainable and scalable organization.
Financial & Resource Management
Develop and manage the annual budget for the entire Biopharma Operations function. Drive operational efficiency and cost-effectiveness without compromising quality or compliance. Oversee capital expenditure planning for equipment and potential facility build-outs. Ensure optimal allocation of resources to meet program timelines and corporate goals.
Requirements for the EVP, Biopharma Operations with a Biotech Firm – Cambridge, MA
Educational Background
An advanced degree (M.S., Ph.D.) in a relevant scientific or engineering discipline (e.g., Chemical Engineering, Biochemistry, Molecular Biology, Pharmaceutical Sciences) is required. An MBA is a plus.
Executive Experience
A minimum of 20 years of progressive experience in the biopharmaceutical industry, with at least 10 years in a senior leadership role (VP level or higher) overseeing multi-faceted operations functions such as CMC, Manufacturing, Supply Chain, and Quality.
Technical Expertise
Deep, hands-on experience with the development and manufacturing of biologics is essential. Experience with advanced modalities such as cell therapy, gene therapy, or mRNA vaccines is highly desirable. Proven expertise in managing CDMO relationships and complex technology transfers.
Regulatory Acumen
Extensive knowledge of global cGMP requirements and regulatory expectations (FDA, EMA, etc.). Must have direct experience supporting late-stage clinical programs and successful BLA/MAA submissions and approvals.
Strategic Mindset
Demonstrated ability to think strategically and translate corporate goals into actionable operational plans. Experience scaling an operations function from early-stage clinical development to commercial launch is a significant advantage.
Leadership Skills
Exceptional leadership, communication, and interpersonal skills. A proven ability to build and lead high-performing teams, influence stakeholders across the organization, and navigate the complexities of a fast-growing biotech environment.
Location
Ability to work on-site at the company’s headquarters in Cambridge, MA, is required. This role demands a significant physical presence to lead the teams and collaborate effectively with the executive staff.
Benefits & Perks Offered
Our client is committed to attracting and retaining top talent by offering a highly competitive and comprehensive compensation and benefits package. This includes:
Competitive Compensation
A highly attractive base salary, annual performance-based bonus, and a significant long-term incentive package (stock options/equity) commensurate with the executive level of this role.
Comprehensive Health & Wellness
Premium medical, dental, and vision insurance for you and your eligible dependents. Wellness programs, employee assistance programs, and flexible spending accounts (FSA/HSA).
Retirement Savings
A robust 401(k) plan with a generous company match to help you plan for your future.
Generous Paid Time Off
A competitive paid time off (PTO) policy, including vacation, sick days, and company-paid holidays, to support a healthy work-life balance.
Professional Development
A strong commitment to your growth with support for attending industry conferences, continuing education, and leadership development programs.
Relocation Assistance
A comprehensive relocation package is available for exceptional candidates who are not local to the Cambridge, MA area.
Inspiring Work Environment
The opportunity to work alongside a passionate and brilliant team of scientists, clinicians, and business leaders in a state-of-the-art facility located in the heart of the world’s leading biotech ecosystem.
How to Apply
This is a retained search managed exclusively by JRG Partners. To be considered for this pivotal leadership position, please submit your resume and a cover letter outlining your qualifications and interest in the role. We encourage you to highlight your experience in scaling biopharma operations and your successes in bringing novel therapies through development to commercialization.
JRG Partners is a leader in executive recruitment for the life sciences sector. Our dedicated consultants possess deep industry knowledge and an extensive network to connect exceptional leaders with innovative companies. To learn more about our expertise or to confidentially discuss your career aspirations, we invite you to connect with the JRG Partners’ Life Sciences executive search team. We are an equal opportunity employer and value diversity at our company and our clients. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All applications will be treated with the strictest confidence.
