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# Chief Commercial Officer for a structural heart company in , Irvine, CA



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  "title" : "Chief Commercial Officer – Structural Heart",
  "description" : "Our client, a high-growth, venture-backed structural heart company, is seeking a Chief Commercial Officer (CCO) to lead their global go-to-market strategy. Based in Irvine, CA, this executive will build and scale the sales, marketing, and market access teams to drive the adoption of a revolutionary portfolio of structural heart therapies. This is a key executive leadership role reporting directly to the CEO, responsible for all revenue-generation and commercialization activities.",
  "jobBenefits" : "A highly competitive executive compensation package, including a significant equity position, annual bonus, and comprehensive benefits.",
  "datePosted" : "2025-11-16",
  "validThrough" : "2026-5-15",
  "employmentType" : "FULL_TIME",
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    "name" : "JRG Partners",
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  "jobLocation": {
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    "address": {
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      "addressLocality": "Irvine",
      "addressRegion": "CA",
      "postalCode": "92618",
      "addressCountry": "US"
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  "responsibilities": "Global Commercial Strategy, US & OUS Sales Leadership, Upstream & Downstream Marketing, Market Access & Reimbursement Strategy, Product Launch Excellence, Commercial Operations & Team Building.",
  "qualifications": "Minimum 15+ years of progressive commercial leadership in the medical device industry. Direct and recent experience in the Structural Heart (e.g., TAVR, TMVR, LAAO) or complex Class III cardiovascular device space is required. Proven track record of scaling a commercial organization from pre-launch to significant revenue. Experience building and leading both sales and marketing functions. Strong relationships with KOLs in interventional cardiology and cardiac surgery. BA/BS required; MBA preferred."
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Chief Commercial Officer – Structural Heart – Irvine, CA
The Opportunity
Our client, a dynamic and well-funded medical device company, is at the forefront of innovation in the structural heart space. They are seeking an experienced and results-driven Chief Commercial Officer (CCO) to join their executive leadership team in Irvine, CA. This is a rare opportunity to build and lead the entire global commercial engine for a company with a disruptive, first-in-class technology portfolio.
Reporting directly to the CEO, the CCO will be responsible for developing and executing the global go-to-market strategy, scaling the sales and marketing organizations, and driving rapid market adoption and revenue growth. This leader will be the primary architect of the company’s commercial success, shaping its future from a pivotal, pre-commercial [or “early-commercial”] stage to market leadership.
About the Organization
Our client is a pioneering medical technology company dedicated to developing novel, minimally-invasive solutions for patients with structural heart disease. Their innovative approach and strong clinical data have positioned them to become a new standard of care. Headquartered in the MedTech hub of Irvine, CA, the company fosters a fast-paced, collaborative, and mission-driven culture focused on saving and improving patient lives.
Key Responsibilities
The CCO will have full P&L responsibility for the commercial organization and will oversee all sales, marketing, market access, and commercial operations functions.
Global Commercial Strategy & Execution

Develop and implement a comprehensive global commercial strategy, including product launch sequencing, pricing, and geographic expansion.
Create and manage sales forecasts, budgets, and the overall commercial P&L.
Establish key performance metrics (KPIs) to monitor and drive commercial performance.
Partner closely with R&D, Clinical, and Regulatory affairs to provide market feedback and ensure pipeline alignment.

Sales Leadership & Revenue Generation

Recruit, build, and lead a high-performing, world-class sales organization, including direct sales, clinical specialists, and channel partners (as needed, for OUS).
Develop and cultivate strong, lasting relationships with Key Opinion Leaders (KOLs) in interventional cardiology and cardiac surgery.
Drive the sales process for a complex, clinically-driven capital and/or disposable device, managing long sales cycles with multiple hospital stakeholders.

Marketing & Product Management

Lead all upstream (product pipeline, voice-of-customer) and downstream (marcom, branding, tradeshows) marketing initiatives.
Develop a compelling global brand and value proposition that differentiates the company’s technology.
Oversee the creation of sales training programs, physician education, and all commercial launch materials.

Market Access & Reimbursement

Design and execute a sophisticated market access and reimbursement strategy to secure favorable coverage and payment from CMS and private payers.
Partner with Health Economics and Outcomes Research (HEOR) to build a robust value-based argument for the technology.
Navigate the complex reimbursement landscapes in both US and key OUS markets.

Team Leadership & Development

Recruit, mentor, and inspire a world-class commercial leadership team across sales, marketing, market access, and sales operations.
Foster a culture of accountability, collaboration, and high performance aligned with the company’s core values.

Candidate Profile & Qualifications
The ideal candidate is a proven, hands-on commercial executive with deep domain expertise in the cardiovascular space and a builder’s mindset.
Required Qualifications

A minimum of 15 years of progressive commercial leadership experience in the medical device industry, with at least 5 years in a senior (VP or C-level) role.
Direct and recent experience in the Structural Heart (e.g., TAVR, TMVR, LAAO) or complex Class III cardiovascular device space is required.
Proven track record of successfully launching novel, disruptive medical devices and scaling a commercial organization from pre-launch to significant revenue ($100M+).
Experience building and leading both sales and marketing functions; a “full-stack” commercial leader.
Demonstrable experience in developing and executing a successful US market access and reimbursement strategy.
Established relationships with key opinion leaders (KOLs) in interventional cardiology and cardiac surgery.
Bachelor’s degree in Business, Marketing, Life Sciences, or a related field.

Preferred Attributes

MBA or other advanced degree is highly preferred.
Experience in both high-growth, venture-backed/start-up environments and large-cap medical device companies.
Experience managing OUS (international) commercial development and sales teams.
A hands-on, metrics-driven, and highly collaborative leadership style.

Compensation & Benefits
A highly competitive executive compensation package will be provided, including a strong base salary, an aggressive annual bonus structure, and a significant equity (stock options) position aligned with the company’s growth.
Location
This position is based at the company’s headquarters in Irvine, CA. This is an on-site executive role requiring a significant presence with the team. Relocation assistance is available.
To Apply
If you are a strategic, innovative, and results-driven commercial leader with a strong background in the structural heart market, medical device commercialization, and operational excellence, we invite you to apply for the Chief Commercial Officer – Structural Heart role in Irvine, CA. This position offers a unique opportunity to lead a high-performing global commercial organization, enhance market adoption, and drive long-term organizational growth.
To apply, please submit your resume and a cover letter outlining your experience in medical device commercial leadership, structural heart (or cardiovascular) market, global product launches, sales force scaling, market access/reimbursement, and KOL development. Highlight your achievements in driving revenue growth, launching new technologies, and building and leading high-performance sales and marketing teams.
This is a high-impact executive role where you will directly influence commercial performance, patient access, and long-term business strategy. Apply today to take the next step in your executive career as Chief Commercial Officer – Structural Heart – Irvine, CA!
For more information or to explore similar opportunities, visit our Medical Device & MedTech Executive Search Firm Page.
Our client is an equal opportunity employer and is committed to building a diverse and inclusive team. We strongly encourage candidates from all backgrounds to apply.